Minas Avetisyan was born in the village of Jajur, Soviet Armenia.
The main theme of his works was Armenian nature, the nature of Jajur, the religion, poor people, mountains, fields etc.
Avetisyan emerged as an artist at the Exhibition of Five in Yerevan (1962). Numerous specialists and visitors to the exhibition appreciated greatly his work. Avetisian's method differs from the method of plain-air painting which was once widespread in Armenian art. For him working form nature is no more than a preliminary stage. The main portion of the work on the canvas was done in his studio.
In his paintings, Avetisyan uses bright and unmixed colors that are juxtaposed with each other to form bold shapes that are clearly defined. A very popular person in Armenia and Soviet Union, Minas was an art dissident who used national elements in his painting style.
In 1975, Minas Avetisyan died under the wheels of the car, which stopped off at the sidewalk. According to some sources, he was murdered by the KGB.